| Boston South Station | WDC Bethesda | 01:00 | 01:11 |
| Boston South Station | Philadelphia | 01:00 | 01:07 |
| Boston South Station | Cherry Hill Mall | 01:00 | 01:10 |
| Boston South Station | Niagara Falls | 01:00 | 01:16 |
| Boston South Station | Syracuse Bus Station | 01:00 | 01:12 |
| Boston South Station | PhiladelphiaSchuylkill and Walnut | 01:00 | 01:10 |
| Boston South Station | Rochester Bus Stop | 01:00 | 01:13 |
| Boston South Station | Binghamton | 01:00 | 01:09 |
| Boston South Station | PhiladelphiaSchuylkill and Walnut | 01:30 | 01:37 |
| Boston South Station | Binghamton | 01:30 | 01:40 |
| Boston South Station | Delaware Rest Stop N | 01:30 | 01:42 |
| Boston South Station | Niagara Falls | 01:30 | 01:46 |
| Boston South Station | Philadelphia | 01:30 | 01:37 |
| Boston South Station | Baltimore Downtown Bus Station | 01:30 | 01:38 |
| Boston South Station | Washington Union Station | 01:30 | 01:40 |
| Boston South Station | Harrisburg Bus Station | 01:30 | 01:42 |
| Boston South Station | Rochester Bus Stop | 01:30 | 01:43 |
| Boston South Station | Richmond North McDonalds Mechanicsville Tpk | 01:30 | 01:44 |
| Boston South Station | New Brunswick | 01:30 | 01:36 |
| Boston South Station | Buffalo Airport | 01:30 | 01:45 |
| Boston South Station | Chicago 95th St Bus Station | 01:30 | 00:59 |
| Boston South Station | Syracuse Bus Station | 01:30 | 01:42 |
| Boston South Station | Buffalo Bus Station | 01:30 | 01:45 |
| Boston South Station | Richmond Richmond th St and Ambler | 01:30 | 01:42 |
| Boston South Station | Richmond Richmond th St and Ambler | 01:30 | 01:43 |
| Boston South Station | Hartford Union Station | 02:15 | 02:16 |
| Boston South Station | Indianapolis Bus Station | 02:15 | 02:40 |
| Boston South Station | Pittsburgh Intermodal Station | 02:15 | 02:31 |
| Boston South Station | Philadelphia | 02:15 | 02:23 |
| Boston South Station | Newark NJ | 02:15 | 02:21 |
| Boston South Station | Ridgewood NJ Northbound | 02:15 | 02:21 |
| Boston South Station | Columbus E Mound St | 02:15 | 02:36 |
| Boston South Station | Atlantic City Tropicana | 02:15 | 02:24 |
| Boston South Station | Atlantic City Caesars | 02:15 | 02:23 |
| Boston South Station | Wilmington Bus Station | 02:15 | 02:23 |
| Boston South Station | Atlantic City Resorts | 02:15 | 02:24 |
| Boston South Station | Baltimore Downtown Bus Station | 02:15 | 02:25 |
| Boston South Station | Cortland City Office Building | 02:15 | 02:25 |
| Boston South Station | NY Port Authority Bus Station | 02:15 | 02:19 |
| Boston South Station | Binghamton | 02:15 | 02:24 |
| Boston South Station | Washington Union Station | 02:15 | 02:27 |
| Boston South Station | Cherry Hill Mall | 02:15 | 02:22 |
| Boston South Station | Ridgewood NJ Northbound | 02:30 | 02:38 |
| Boston South Station | Greensboro Bus Stop | 02:30 | 02:50 |
| Boston South Station | Chicago Bus Station | 02:30 | 01:58 |
| Boston South Station | State College Univ Park Airport | 02:30 | 02:43 |
| Boston South Station | Pittsburgh Intermodal Station | 02:30 | 02:46 |
| Boston South Station | Harrisburg Bus Station | 02:30 | 02:42 |
| Boston South Station | Allentown Allentown Bus Stop | 02:30 | 02:39 |
| Boston South Station | Buffalo Airport | 02:30 | 02:45 |
| Boston South Station | Newark DE | 02:30 | 02:41 |
| Boston South Station | Delaware Rest Stop S | 02:30 | 02:38 |
| Boston South Station | Charlotte Bus Station | 02:30 | 02:52 |
| Boston South Station | Dayton Huber Heights | 02:30 | 02:52 |
| Boston South Station | Columbus | 02:30 | 02:50 |
| Boston South Station | Indianapolis E Washington St | 02:30 | 02:54 |
| Boston South Station | Richmond Richmond th St and Ambler | 02:30 | 02:43 |
| Boston South Station | White Plains Bus Station | 05:00 | 05:04 |
| Boston South Station | Bangor Park and Ride | 05:10 | 05:14 |
| Boston South Station | Waterville J and S Oil Co | 05:10 | 05:16 |
| Boston South Station | Portland Park and Ride | 05:15 | 05:17 |
| Boston South Station | Atlanta Bus Station | 06:00 | 06:23 |
| Boston South Station | Raleigh Bus Station | 06:00 | 06:15 |
| Boston South Station | Richmond Main St Station Plaza | 06:00 | 06:11 |
| Boston South Station | Charlotte Bus Station | 06:00 | 06:18 |
| Boston South Station | Cortland Onvo Travel Plaza | 06:00 | 06:10 |
| Boston South Station | Camden Walter Rand Trans Center | 06:45 | 06:52 |
| Boston South Station | Rochester Bus Stop | 07:00 | 07:08 |
| Boston South Station | Buffalo Airport | 07:00 | 07:11 |
| Boston South Station | Syracuse Bus Station | 07:00 | 07:06 |
| Boston South Station | Niagara Falls | 07:00 | 07:12 |
| Boston South Station | White River Junction Bus Station | 07:00 | 07:02 |
| Boston South Station | Burlington Downtown Transit Ctr | 07:00 | 07:04 |
| Boston South Station | Albany Bus Terminal NY | 07:00 | 07:03 |
| Boston South Station | Cortland City Office Building | 07:00 | 07:12 |
| Boston South Station | New Britain JimmyS Food Mart 1 | 07:00 | 07:03 |
| Boston South Station | Montreal Gare d autocars de Montreal | 07:00 | 07:07 |
| Boston South Station | Schenectady Gateway Mobility Hub | 07:00 | 07:04 |
| Boston South Station | Ridgewood NJ Southbound | 07:00 | 07:09 |
| Boston South Station | Buffalo Bus Station | 07:00 | 07:10 |
| Boston South Station | Binghamton | 07:00 | 07:08 |
| Boston South Station | Toronto Union Station Bus Terminal | 07:00 | 07:14 |
| Boston South Station | Providence Convention Center | 07:15 | 07:16 |
| Boston South Station | Atlanta Bus Station | 07:20 | 07:46 |
| Boston South Station | Greensboro Bus Stop | 07:20 | 07:38 |
| Boston South Station | Raleigh Bus Station | 07:20 | 07:36 |
| Boston South Station | Charlotte Bus Station | 07:20 | 07:40 |
| Boston South Station | Pittsburgh Intermodal Station | 07:20 | 07:35 |
| Boston South Station | Baltimore Downtown Bus Station | 07:20 | 07:28 |
| Boston South Station | State College Bus Station | 07:20 | 07:32 |
| Boston South Station | PhiladelphiaSchuylkill and Walnut | 07:20 | 07:27 |
| Boston South Station | Allentown Allentown Bus Stop | 07:20 | 07:30 |
| Boston South Station | Newark NJ | 08:00 | 08:05 |
| Boston South Station | Washington Union Station | 08:00 | 08:09 |
| Boston South Station | Syracuse Bus Station | 08:00 | 08:10 |
| Boston South Station | Buffalo Bus Station | 08:00 | 08:14 |
| Boston South Station | Ithaca | 08:00 | 08:10 |
| Boston South Station | Binghamton | 08:00 | 08:08 |
| Boston South Station | Baltimore Downtown Bus Station | 08:00 | 08:08 |
| Boston South Station | Cortland Onvo Travel Plaza | 08:00 | 08:09 |