| Class | Departure Station | Arrival Station | Departure | Arrival | Travel time |
|---|---|---|---|---|---|
| Express | Asuncion Bus Station | San Roque Gonzalez | 04:00 | 07:10 | 3h 10m |
| Express | San Roque Gonzalez | Asuncion Bus Station | 15:20 | 18:30 | 3h 10m |
| Express | Asuncion Bus Station | San Roque Gonzalez | 06:00 | 09:10 | 3h 10m |
| Express | Asuncion Bus Station | San Roque Gonzalez | 07:00 | 10:10 | 3h 10m |
| Express | Asuncion Bus Station | San Roque Gonzalez | 08:00 | 11:10 | 3h 10m |
| Express | Asuncion Bus Station | San Roque Gonzalez | 09:00 | 12:10 | 3h 10m |
| Express | Asuncion Bus Station | San Roque Gonzalez | 10:00 | 13:10 | 3h 10m |
| Express | Asuncion Bus Station | San Roque Gonzalez | 11:00 | 14:10 | 3h 10m |
| Express | Asuncion Bus Station | San Roque Gonzalez | 11:30 | 14:40 | 3h 10m |
| Express | Asuncion Bus Station | San Roque Gonzalez | 12:00 | 15:10 | 3h 10m |
| Express | Asuncion Bus Station | San Roque Gonzalez | 04:30 | 07:40 | 3h 10m |
| Express | Asuncion Bus Station | San Roque Gonzalez | 14:00 | 17:10 | 3h 10m |
| Express | Asuncion Bus Station | San Roque Gonzalez | 15:00 | 18:10 | 3h 10m |
| Express | Asuncion Bus Station | San Roque Gonzalez | 16:00 | 19:10 | 3h 10m |
| Express | Asuncion Bus Station | San Roque Gonzalez | 16:50 | 20:00 | 3h 10m |
| Express | Asuncion Bus Station | San Roque Gonzalez | 17:30 | 20:40 | 3h 10m |
| Express | Asuncion Bus Station | San Roque Gonzalez | 18:00 | 21:10 | 3h 10m |
| Express | Asuncion Bus Station | San Roque Gonzalez | 19:00 | 22:10 | 3h 10m |
| Express | San Roque Gonzalez | Asuncion Bus Station | 02:20 | 05:30 | 3h 10m |
| Express | San Roque Gonzalez | Asuncion Bus Station | 03:40 | 06:50 | 3h 10m |
| Express | San Roque Gonzalez | Asuncion Bus Station | 04:20 | 07:30 | 3h 10m |
| Express | San Roque Gonzalez | Asuncion Bus Station | 05:20 | 08:30 | 3h 10m |
| Express | San Roque Gonzalez | Asuncion Bus Station | 06:20 | 09:30 | 3h 10m |
| Express | San Roque Gonzalez | Asuncion Bus Station | 07:20 | 10:30 | 3h 10m |
| Express | San Roque Gonzalez | Asuncion Bus Station | 08:20 | 11:30 | 3h 10m |
| Express | San Roque Gonzalez | Asuncion Bus Station | 09:20 | 12:30 | 3h 10m |
| Express | San Roque Gonzalez | Asuncion Bus Station | 10:20 | 13:30 | 3h 10m |
| Express | San Roque Gonzalez | Asuncion Bus Station | 11:20 | 14:30 | 3h 10m |
| Express | San Roque Gonzalez | Asuncion Bus Station | 12:20 | 15:30 | 3h 10m |
| Express | San Roque Gonzalez | Asuncion Bus Station | 13:20 | 16:30 | 3h 10m |